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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment choice for chronic weight loss in addition to a reduced-calorie diet and exercising.

Using two separate drugs to shed pounds can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight loss and the people who go through it you need to err assisting caution and permit the FDA do its job and demand some study be done so the public recognizes the side effects and perils associated with the medications before we take them. Keep in mind that drug companies have been in business to make money and that they would say anything to keep people on his or her medications.

Researchers found that participants taking this drug for any year, dropped excess weight within four weeks and have kept the body weight off throughout the 56 weeks in the study. Contrave is really a combination in the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which can be made up of several active ingredient, which might make them more effective and safer.

Combo-pilling is the newest fad or in addition to this the newest ahead under scrutiny and thus it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular may be the fact that at the time of right now there aren't any long term prescription weightloss pills that have been licensed by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations happen to be rejected or have yet to be licensed by the FDA.

Seizures can be a side effect with Contrave and really should not be taken in those with seizure disorders. The drug also can raise blood pressure levels and heartbeat, and mustn't be used in individuals with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure and heart rate and must not used in patients with uncontrolled high blood pressure levels, as well as by you aren't heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients using a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients on the increased risk of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking.


Suboxone consists of two drugs; buprenorphine and naloxone. The naloxone is irrelevant when the addict uses the medication properly, but if your tablet is dissolved in water and injected the naloxone can cause instant withdrawal. When suboxone is used correctly, the naloxone is destroyed inside the liver shortly after uptake in the intestines and possesses no therapeutic effect. Buprenorphine could be the active substance; it really is absorbed underneath the tongue (and through the mouth) but destroyed with the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I manipulate this formulation when the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have also treated addicts who may have had gastric bypass, where the first part of the intestine is bypassed and also the stomach contents empty right into a more distal section of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the method with normal anatomy where the drug is taken up from the duodenum and transferred right to the liver from the portal vein, where it really is quickly and completely destroyed. After gastric bypass naloxone can be used up by areas of the intestine that aren't served from the portal system, causing blood degrees of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.