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The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in older adults with a body mass index (BMI) in excess of 27, provided that they also suffer from weight-related health concerns such as Tupe2 diabestes, high-cholesterol and/or hypertension (high blood pressure).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so that as an aid to stop smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle including a reduced-calorie eating and working out, Contrave provides another treatment choice for chronic weight reduction for people who are obese or are overweight and also have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated first year. All patients received lifestyle modification that contained a reduced- calorie diet and regular exercise. Results from a clinical trial that enrolled patients without diabetes established that patients had the average weight loss of four.1% in contrast to participants who were given placebos) after a 12- month period, while an outside study involving patients with diabetes type 2 symptoms had a normal weight loss of 2% over treatment with placebo at one full year.

Using two separate drugs to shed pounds can be very effective there are combinations while watching FDA now awaiting approval. When dealing with weight loss and the individuals who go through it one should err on the side of caution and permit the FDA do its job and demand some investigation be done in order that the public knows the side effects and hazards of the medications before we take them. Keep in mind that drug companies are in business to generate income and that they would say almost anything to keep people on their medications.

Researchers found out that participants taking this drug for the year, dropped a few pounds within one month and have kept the body weight off through the entire 56 weeks of the study. Contrave is a combination in the drugs naltrexone and bupropion, which seems to reflect a whole new trend of weight-loss drugs which might be made up of several active ingredient, that might make them more efficient and safer.

Combo-pilling could be the newest fad or even better the newest to come under scrutiny and so it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that employing a combination of pills is starting to become popular will be the fact that by right now there are no long term prescription slimming capsules that have been approved by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be licensed by the FDA.

Seizures certainly are a side effect with Contrave and really should not be taken in people who have seizure disorders. The drug may also raise blood pressure level and heartrate, and mustn't be used in people with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise blood pressure levels and heartbeat and must not used in patients with uncontrolled high blood pressure levels, in addition to by you are not heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients which has a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients on the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation.



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